Sri Harshavardhan Malapati (3283)

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Wallerian Degeneration in ALS

Hometown: McLean, Virginia

Department: Biology 

Advisor: John Swaddle

The most common genetic cause of Amyotrophic Lateral Sclerosis (ALS) is a mutation in the C9orf72 gene, but the pathway through which this mutation causes axon degeneration is not yet known. I hypothesize that SARM1, a central member of the axon degeneration pathway, is involved; and, my research will use avian neurons to understand if and how SARM1 is activated by mutations in C9. This approach could open up new therapeutic possibilities for those living with ALS. Thank you for the support!

All William & Mary Honors Fellowships fundraising supports the Charles Center Honors Fellowships Fund. Direct support for individual undergraduate research projects is distributed by the Roy R. Charles Center for Academic Excellence

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