Harshini Malapati (3283)

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The Impact of Thyroid Hormone Receptor Mutations on the Development of Liver Cancer

Hometown: McLean, Virginia

Department: Biology

Advisor: Lizabeth Allison


A thyroid hormone receptor (TR) mutant that consists of four changes in its amino acid sequence (S40T, K136R, L251P, V390A) were observed in a patient with hepatocellular carcinoma. I have found that unlike normal TR, TR with these mutations are abnormally distributed and form aggregates within cells. Aggregates of certain proteins such as p53 are known to be associated with cancer. My Honors Thesis focuses on the impact of these TR mutations and aggregates on development of liver cancer.


All William & Mary Honors Fellowships fundraising supports the Charles Center Honors Fellowships Fund. Direct support for individual undergraduate research projects is distributed by the Roy R. Charles Center for Academic Excellence

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