An Anonymous Donor matched $700RNF4's Role in Stripping Transcriptionally-Active Huntington on a Genome Wide Level
Hometown: Nashville, Tennessee
Department: Biology
Advisor: Oliver Kerscher
Description: Altered gene expression is a hallmark of neurodegenerative disorders such as Huntington's Disease. The causative agent of Huntington's is a mutant, aggregation-prone form of huntingtin (htt) that accumulates in neuronal cells but is degraded by human RNF4. We will investigate whether RNF4 reduces the transcriptional activity of mutant htt in a tissue culture model of Huntington's and the role that RNF4 plays in inhibiting transcriptionally-active huntingtin.
All William & Mary Honors Fellowships fundraising supports the Charles Center Honors Fellowships Fund. Direct support for individual undergraduate research projects is distributed by the Roy R. Charles Center for Academic Excellence.
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