Title: Novel Synthesis Pathway of 1,4-Oxazinone using ß-amino alcohols
Department: Chemistry
Description: The purpose of this project is to develop a new method of synthesizing 1,4-oxazinones using widely available amino alcohol precursors. Oxazinones (Product 1, Figure 1) are fascinating and understudied heterocyclic ring systems that have their own respective importance but are also reactive intermediates that lead to the production of pyridines. Pyridines (Product 2, Figure 1) are the second most common nitrogen-containing ring structure found in FDA approved therapeutic molecules such as anti-cancer and anti-malarial agents. Currently, there are limited methods of synthesizing oxazinones. This proposed pathway (see Figure 1) is a novel method for synthesizing oxazinone using ß-amino alcohols (Reagent B, Figure 1) as a precursor. Therefore, this project will both provide a new method for oxazinone synthesis, but also has synthetic utility in downstream synthesis of pyridines.
Hometown: Glen Allen, Virginia
Advisor: Jonathan Scheerer
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