Title: Characterizing the function of the predicted nematode pseudophosphatase SPE-54 through analysis of its subcellular localization, catalytic activity and molecular evolution
Department: Biology
Description: Using the model system C. elegans, a millimeter long worm, this study will examine a protein known as a pseudophosphatase, called SPE-54, necessary for C. elegans to make successfully crawling sperm. Relying on a genetically modified worm lineage to make SPE-54 easier to see, this research will describe where and when the protein is seen during the process of making mature sperm. By describing where the protein is found, clues can be found about how SPE-54 functions. Different locations in developing nematode sperm cells are responsible for distinct developmental events. SPE-54 found in the spermatozoan pseudopod, for example, might suggest SPE-54 is involved in the assembly and polymerization of the sperm mobility apparatus. Details about the location and clues about the function of this nematode pseudophosphatase may provide insight into how humans and other mammals produce motile sperm, as they also rely upon pseudophosphatases.
Hometown: Fairfax, Virginia
Advisor: Diane Carol Shakes
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